Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

Background and aim COVID-19 pandemic has resulted in an unprecedented increased
usage of Personal protective equipment (PPE) by healthcare-workers. PPE usage causes …

Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain
diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in …

Key points Preclinical models have demonstrated that nitric oxide is a key component of
neurovascular coupling; this has yet to be translated to humans. We conducted two separate …

Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of
vascular function with links to coronary artery health and cardiovascular risk. Cerebral …

Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular
endothelial function. We recently introduced a test of cerebral shear‐mediated dilatation …

Key points Intermittent hypoxia leads to long‐lasting increases in muscle sympathetic nerve
activity and blood pressure, contributing to increased risk for hypertension in obstructive …

Evidence for shear stress as a regulator of carotid artery dilation in response to increased
arterial CO2 was recently demonstrated in humans during sustained elevations in CO2 …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …