Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Mimicking antioxidases and Hyaluronan synthase: a zwitterionic nanozyme for Photothermal Therapy of Osteoarthritis

P Yu, Y Li, H Sun, H Zhang, H Kang, P Wang… - Advanced …, 2023 - Wiley Online Library
Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are
limited to unilateral efforts in joint lubrication, inhibition of inflammation, free radicals …

Challenges and controversies in human mesenchymal stem cell therapy

B Lukomska, L Stanaszek, E Zuba-Surma… - Stem cells …, 2019 - Wiley Online Library
Stem cell therapy is being intensely investigated within the last years. Expectations are high
regarding mesenchymal stem cell (MSC) treatment in translational medicine. However …

[HTML][HTML] Osteoarthritis year in review 2019: epidemiology and therapy

M Kloppenburg, F Berenbaum - Osteoarthritis and cartilage, 2020 - Elsevier
Over the past year many studies and clinical trials have been published in the osteoarthritis
(OA) field. This review is based on systematic literature review covering the period May 1 st …

Intra-articular treatment options for knee osteoarthritis

IA Jones, R Togashi, ML Wilson, N Heckmann… - Nature Reviews …, 2019 - nature.com
Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

CrossFit overview: systematic review and meta-analysis

JG Claudino, TJ Gabbett, F Bourgeois, HS Souza… - Sports medicine …, 2018 - Springer
Background CrossFit is recognized as one of the fastest growing high-intensity functional
training modes in the world. However, scientific data regarding the practice of CrossFit is …

[HTML][HTML] Osteoarthritis year in review 2018: clinical

LA Mandl - Osteoarthritis and cartilage, 2019 - Elsevier
Osteoarthritis (OA) is the most common joint disease in the world, with an age-associated
increase in both incidence and prevalence. Clinical and epidemiologic research is crucial to …

PRP injections for the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials

G Filardo, D Previtali, F Napoli, C Candrian… - Cartilage, 2021 - journals.sagepub.com
Objective To evaluate effectiveness, in terms of patient-reported outcome measures, of
platelet-rich plasma (PRP) injections for knee osteoarthritis compared to placebo and other …

[HTML][HTML] Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition)

Z Zhang, C Huang, Q Jiang, Y Zheng, Y Liu… - Annals of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a degenerative disease of middle-aged and elderly people, contributed
a higher burden of disease in China and the world. In 2017, under the support of the …