Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

Autoimmune disease encompasses an array of conditions with a variety of presentations
and the involvement of multiple organs. Though the etiologies of many autoimmune …

Objective Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated
growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory …

Gaucher disease (GD), the most common lysosomal storage disease, is caused by
mutations in GBA1 encoding of β-glucocerebrosidase (GCase). Recently it was reported that …

Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a
secreted growth factor that implicates in a multitude of processes ranging from regulation of …

Progranulin (PGRN), a widely expressed glycoprotein with pleiotropic function, has been
linked to a host of physiological processes and diverse pathological states. A series of …

Background Gaucher disease (GD) is a genetic disease caused by mutations in the GBA1
gene which result in reduced enzymatic activity of β-glucocerebrosidase (GCase). This study …

Progranulin (PGRN) has been shown to be involved in the process of inflammation, wound
healing, and cartilage development; and its role in the progression of breast and ovarian …

Sortilin, also known as Neurotensin Receptor-3, and the sorting-related receptor with type-A
repeats (SorLA) are both members of the Vps10p domain receptor family. Initially identified …

Background Peripheral nerve injury is a frequent cause of lasting motor deficits and chronic
pain. Although peripheral nerves are capable of regrowth they often fail to re-innervate …