Cancer research relies on model systems, which reflect the biology of actual human tumours
to only a certain extent. One important feature of human cancer is its intra-tumour genomic …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Understanding the genetic basis of a predisposition for nicotine and alcohol use across the
lifespan is important for public health efforts because genetic contributions may change with …

C57BL/6 inbred strains of mice are widely used in knockout and transgenic research. To
evaluate the loss-of-function and gain-of-function effects of the gene of interest, animal …

Separate breeding colonies of C57BL/6 (“B6”) mice maintained at the Jackson Laboratories
(“J”) and NIH (“N”) have led to the emergence of two distinct substrains of C57BL/6 mice …

Mice from the inbred C57BL/6 strain have been commonly used for the generation and
analysis of transgenic and knockout animal models. However, several C57BL/6 substrains …

The C57BL/6J (B6/J) male mouse represents a standard for diet‐induced obesity (DIO) and
is unique in expressing a loss‐of‐function nicotinamide nucleotide transhydrogenase (Nnt) …

El objetivo del estudio fue analizar las percepciones acerca del embarazo y aborto en dos
grupos de mujeres. Se encuestó a 100 adolescentes ya 100 jóvenes adultas de la ciudad …

The identification of early and stage-specific biomarkers for Alzheimer's disease (AD) is
critical, as the development of disease-modification therapies may depend on the discovery …

The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on
the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial …