Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Gut microbial metabolites as multi-kingdom intermediates

KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Gut microbial carbohydrate metabolism contributes to insulin resistance

T Takeuchi, T Kubota, Y Nakanishi, H Tsugawa… - Nature, 2023 - nature.com
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

A Lavelle, H Sokol - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …

A reference map of potential determinants for the human serum metabolome

N Bar, T Korem, O Weissbrod, D Zeevi, D Rothschild… - Nature, 2020 - nature.com
The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …

Human postprandial responses to food and potential for precision nutrition

SE Berry, AM Valdes, DA Drew, F Asnicar, M Mazidi… - Nature medicine, 2020 - nature.com
Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-
resolution studies are lacking. We recruited n= 1,002 twins and unrelated healthy adults in …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Prolonged impairment of short-chain fatty acid and L-isoleucine biosynthesis in gut microbiome in patients with COVID-19

F Zhang, Y Wan, T Zuo, YK Yeoh, Q Liu, L Zhang… - Gastroenterology, 2022 - Elsevier
Background and Aims Coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut …

Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders

J Yang, P Zheng, Y Li, J Wu, X Tan, J Zhou, Z Sun… - Science …, 2020 - science.org
Gut microbiome disturbances have been implicated in major depressive disorder (MDD).
However, little is known about how the gut virome, microbiome, and fecal metabolome …