[HTML][HTML] Triazoles and their derivatives: Chemistry, synthesis, and therapeutic applications

MM Matin, P Matin, MR Rahman… - Frontiers in molecular …, 2022 - frontiersin.org
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …

Emerging building blocks for medicinal chemistry: recent synthetic advances

OO Grygorenko, DM Volochnyuk… - European Journal of …, 2021 - Wiley Online Library
Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …

Radical Hydro‐Fluorosulfonylation of Unactivated Alkenes and Alkynes

P Wang, H Zhang, M Zhao, S Ji, L Lin… - Angewandte Chemie …, 2022 - Wiley Online Library
Recently, radical fluorosulfonylation is emerging as an appealing approach for the synthesis
of sulfonyl fluorides, which are highly in demand in various disciplines, particularly in …

Electrochemical Oxo‐Fluorosulfonylation of Alkynes under Air: Facile Access to β‐Keto Sulfonyl Fluorides

D Chen, X Nie, Q Feng, Y Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Radical fluorosulfonylation is emerging as an appealing approach for the synthesis of
sulfonyl fluorides, which have widespread applications in many fields, in particular in the …

[HTML][HTML] An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities

SA Khan, MJ Akhtar, U Gogoi, DU Meenakshi, A Das - Pharmaceuticals, 2023 - mdpi.com
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

Introducing A New Class of Sulfonyl Fluoride Hubs via Radical Chloro‐Fluorosulfonylation of Alkynes

X Nie, T Xu, Y Hong, H Zhang, C Mao… - Angewandte Chemie …, 2021 - Wiley Online Library
Sulfonyl fluorides have widespread applications in many important fields, including ligation
chemistry, chemical biology, and drug discovery. Therefore, new methods to increase the …

Radical fluorosulfonylation: accessing alkenyl sulfonyl fluorides from alkenes

X Nie, T Xu, J Song, A Devaraj, B Zhang… - Angewandte …, 2021 - Wiley Online Library
Sulfonyl fluorides have widespread applications in many fields. In particular, their unique
biological activity has drawn considerable research interest in the context of chemical …

Linkage chemistry of S (VI) fluorides

D Zeng, WP Deng, X Jiang - Chemistry–A European Journal, 2023 - Wiley Online Library
Sulfur (VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced
by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction …

Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs

S Sun, JA Homer, CJ Smedley, QQ Cheng… - Chem, 2023 - cell.com
Phosphorus fluoride exchange (PFEx) represents a cutting-edge advancement in catalytic
click-reaction technology. Drawing inspiration from nature's phosphate connectors, PFEx …

Radical Fluorosulfonyl Heteroarylation of Unactivated Alkenes with Quinoxalin-2(1H)-ones and Related N-Heterocycles

L Lin, P Wang, T Dong, GC Tsui, S Liao - Organic Letters, 2023 - ACS Publications
The incorporation of sulfonyl fluoride groups into molecules has been proved effective to
enhance their biological activities or introduce new functions. Herein, we report a transition …