Natural products (NPs), especially those from traditional herbal medicines, can evidently
modulate human gene expression at multiple levels, leading to a wide diversity of …

The abnormal expression of human DNA methyltransferases (DNMTs) is closely related with
the occurrence and development of a wide range of human cancers. DNA (cytosine-5) …

Abnormal DNA methylation is closely related to the occurrence and development of many
diseases. The determination of human DNA methyltransferase activity and the screening of …

The anthraquinone scaffold has long been known as a source of efficacious antitumor drugs.
In particular, the various chemical modifications of the side chains in this scaffold have …

Aims: The pathogenesis of osteoarthritis (OA) is characterized by oxidative stress (OS) and
sustained inflammation that are substantially associated with epigenetic DNA methylation …

DNA is packaged in an octamer of histones, forming chromatin, a complex of DNA and
proteins. The structural matrix of a chromosome, chromatin and its changes are now …

In eukaryotes, the most common epigenetic DNA modification is methylation of carbon 5 of
cytosines, predominantly in CpG dinucleotides. Methylation patterns are established and …

Hydroxyanthraquinones from plants have been used as both medicinal active ingredients
and adulterants in slimming food supplements. Although sensible doses of certain natural …

Aims: The pathogenesis of osteoarthritis (OA) is characterized by oxidative stress (OS) and
sustained inflammation that are substantially associated with epigenetic DNA methylation …

DNA methyltransferase 1 (DNMT1) is the enzyme primarily responsible for propagation of
the methylation pattern in cells. Mutations in DNMT1 have been linked to the development of …