Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

The use of the dual recombinase-mediated intersectional genetic approach involving Cre-
loxP and Dre-rox has significantly enhanced the precision of in vivo lineage tracing, as well …

Abstract Indoleamine 2, 3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine
metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …

Cardiac regeneration involves the generation of new cardiomyocytes from cycling
cardiomyocytes. Understanding cell-cycle activity of pre-existing cardiomyocytes provides …

Magnetic particle imaging (MPI) is an emerging non‐invasive tomographic technique based
on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of …

Heart failure or myocardial infarction (MI) is one of the world's leading causes of death. Post
MI, the heart can develop pathological conditions such as ischemia, inflammation, fibrosis …

Understanding how macrophages promote myocardial repair can help create new therapies
for infarct repair. We aimed to determine what mechanisms underlie the reparative …

Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …