A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases

AE Lew-Tabor, MR Valle - Ticks and tick-borne diseases, 2016 - Elsevier
The field of reverse vaccinology developed as an outcome of the genome sequence
revolution. Following the introduction of live vaccinations in the western world by Edward …

Modulation of host immunity by tick saliva

J Kotál, H Langhansová, J Lieskovská, JF Andersen… - Journal of …, 2015 - Elsevier
Next generation sequencing and proteomics have helped to comprehensively characterize
gene expression in tick salivary glands at both the transcriptome and the proteome level …

Recent advances in tick antigen discovery and anti-tick vaccine development

MN Abbas, MA Jmel, I Mekki, I Dijkgraaf… - International Journal of …, 2023 - mdpi.com
Ticks can seriously affect human and animal health around the globe, causing significant
economic losses each year. Chemical acaricides are widely used to control ticks, which …

Host immune responses to salivary components-a critical facet of tick-host interactions

A Ali, I Zeb, A Alouffi, H Zahid, MM Almutairi… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick sialome is comprised of a rich cocktail of bioactive molecules that function as a tool to
disarm host immunity, assist blood-feeding, and play a vibrant role in pathogen …

Wonders of tick saliva

PA Nuttall - Ticks and tick-borne diseases, 2019 - Elsevier
Saliva of ticks is arguably the most complex saliva of any animal. This is particularly the case
for ixodid species that feed for many days firmly attached to the same skin site of their …

Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding

TK Kim, L Tirloni, AFM Pinto, J Moresco… - PLoS neglected …, 2016 - journals.plos.org
Ixodes scapularis is the most medically important tick species and transmits five of the 14
reportable human tick borne disease (TBD) agents in the USA. This study describes LC …

Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction

J Chmelař, J Kotál, H Langhansová… - Frontiers in cellular and …, 2017 - frontiersin.org
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of
research of tick protease inhibitors, which represent important constituents of the proteins …

TickSialoFam (TSFam): a database that helps to classify tick salivary proteins, a review on tick salivary protein function and evolution, with considerations on the tick …

JMC Ribeiro, BJ Mans - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Tick saliva contains a complex mixture of peptides and non-peptides that counteract their
hosts' hemostasis, immunity, and tissue-repair reactions. Recent transcriptomic studies have …

Rhipicephalus microplus: An overview of vaccine antigens against the cattle tick

DFS Pereira, HS Ribeiro, AAM Gonçalves… - Ticks and tick-borne …, 2022 - Elsevier
Rhipicephalus microplus, popularly known as the cattle tick, is the most important tick of
livestock as it is responsible for significant economic losses. The use of chemical acaricides …

Potential mechanisms of transmission of tick-borne viruses at the virus-tick interface

M Maqbool, MS Sajid, M Saqib, FR Anjum… - Frontiers in …, 2022 - frontiersin.org
Ticks (Acari; Ixodidae) are the second most important vector for transmission of pathogens to
humans, livestock, and wildlife. Ticks as vectors for viruses have been reported many times …