Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell
dysfunction, production of autoantibodies directed toward cellular and nuclear components …

A number of polymorphisms in immune‐regulatory genes have been identified as risk
factors for the development of autoimmune disease. PTPN 22 (that encodes a tyrosine …

Acetaminophen (APAP) overdosing is a major cause of acute liver failure worldwide and an
established model for drug-induced acute liver injury (ALI). While studying gene expression …

The 1858C> T allele of the tyrosine phosphatase PTPN22 is present in 5–10% of the North
American population and is strongly associated with numerous autoimmune diseases …

Protein tyrosine phosphatases (PTPs) play central roles in the regulation of cell signaling,
organismal development, cellular differentiation and proliferation, and cancer. In the immune …

Marine mammals in the Barents Sea region have among the highest levels of contaminants
recorded in the Arctic and the Atlantic walrus (Odobenus rosmarus rosmarus) is one of the …

An allelic variant of the protein tyrosin phosphatase non-receptor 22 (PTPN22) gene,
PTPN22 R620W, constitutes the strongest non-HLA genetic risk factor for the development …

Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by
immune cells in the pancreas. Pro-inflammatory including TNF-α, IFN-γ and IL-1β are …

A genetic variant of the protein tyrosine phosphatase non-receptor 22 (PTPN22) is
associated with a wide range of autoimmune diseases; however, the reasons behind its …

Миастения гравис тяжелое прогрессирующее аутоиммунное заболевание,
характеризующееся выработкой антител к структурам нервно-мышечного соединения …