Honey contains many active constituents and antioxidants such as polyphenols.
Polyphenols are phytochemicals, a generic term for the several thousand plant-based …

Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular
and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of …

Vascular endothelial dysfunction is regarded as the initial step of vascular complications in
diabetes mellitus. This study investigated the amelioration of apigenin and naringenin in …

Background: Although a high intake of some flavonoid subclasses may reduce
cardiovascular disease mortality, data regarding the in vivo mechanisms of action are …

Aims Doxorubicin, an antibiotic belonging to anthracycline family, has been used for
treatment of malignancies. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin …

Aims Cardiotoxicity is associated with doxorubicin (DOX), an effective anticancer drug.
Apigenin has cardioprotective properties; it may be employed as a capping and reducing …

Abstract Apigenin, identified as 4′, 5, 7‐trihydroxyflavone, is a natural flavonoid compound
present in a variety of fruits, vegetables, functional foods, and medicinal plants. Many studies …

Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous
intercellular messenger involved in the modulation of several processes, such as blood flow …

Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune
diseases and tumors. Oxidative stress and inflammation are involved in the pathogenesis of …

Apigenin, belonging to a less toxic and non-mutagenic flavone subclass of flavonoids, has
been reported to possess numerous biological activities beneficial to health. Although …