Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

The adrenal gland is a source of sex steroid precursors, and its activity is particularly
relevant during fetal development and adrenarche. Following puberty, the synthesis of …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Significant advances have taken place in our knowledge of the enzymes involved in steroid
hormone biosynthesis since the last comprehensive review in 1988. Major developments …

Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary
gland, uterus, brain and other target tissues for estrogen action, and this results in the …

Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone
secreted in large amounts by the adrenals in humans and other primates, but not in lower …

Sex steroids are essential for skeletal development and the maintenance of bone health
throughout adult life, and estrogen deficiency at menopause is a major pathogenetic factor …

Ultraviolet (UV) filters are used widely in cosmetics, plastics, adhesives and other industrial
products to protect human skin or products against direct exposure to deleterious UV …

Context: Disorders of sex development (DSD) are clinical conditions where there is a
discrepancy between the chromosomal sex and the phenotypic (gonadal or genital) sex of …