Leukocytes play a major role in combating infections either by phagocytosis, release of
antimicrobial granules, or extracellular trap (ET) formation. ET formation is preceded by a …

Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting
OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc …

Rationale COPD has been associated repeatedly with single biomarkers of systemic
inflammation, ignoring the complexity of inflammatory pathways. This study aimed to cluster …

Abstract Background Scleroderma (SSc) is a rare autoimmune disease characterized by
vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a …

Our previous findings show that invariant natural killer T (iNKT) cells can promote
immunogenic maturation of lung dendritic cells (LDCs) to enhance Th2 cell responses in …

The interleukin‐1 family member IL‐33 participates in both innate and adaptive T helper‐2
immune cell responses in models of lung disease. The IL‐6‐type cytokine Oncostatin M …

Our previous studies have showed that sulfatide-reactive type II NKT (ie variant NKT, vNKT)
cells inhibit the immunogenic maturation during the development of mature lung dendritic …

Type I interferons (IFNs) consist of a group of structurally similar cytokines that play an
integral role in regulating the immune response to combat lung infections. In certain models …

Adipose tissue homeostasis depends on interactions between stromal cells, adipocytes, and
the cytokines and chemokines they produce. The gp130 cytokine, oncostatin M (OSM), plays …

Background Rheumatoid arthritis (RA) remains a long-standing inflammatory syndrome
where the joint synovial membrane is inflamed, with subsequent joint deformation …