Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …

Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ)
polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage …

During the past decade, it has become apparent that a set of ostensibly unrelated
neurodegenerative diseases, including Parkinson's disease and Huntington's disease …

▪ Abstract In the not-so-distant past, insoluble aggregated protein was considered as
uninteresting and bothersome as yesterday's trash. More recently, protein aggregates have …

With the advent of the key discovery in the mid-1980s that the amyloid β-protein (Aβ) is the
core constituent of the amyloid plaque pathology found in Alzheimer disease (AD), an …

Pancreatic amyloid is formed by the aggregation of the 37-residue islet amyloid polypeptide
(IAPP) in type II diabetes patients and is cytotoxic. Pancreatic amyloid deposits are found in …

The amyloid β (Aβ) peptide and its shorter variants, including a highly cytotoxic Aβ25–35
peptide, exert their neurotoxic effect during Alzheimer's disease by various mechanisms …

The design and application of an effective, new class of organofluorine inhibitors of amyloid
fibrillogenesis are described. Based on experimental evidence a core structure containing …

Despite major efforts aimed at elucidating the molecular basis and physiopathology of
Alzheimer's disease (AD), there is still no effective treatment available for this devastating …