Epidemiology of community-acquired and recurrent Clostridioides difficile infection
Y Fu, Y Luo, AM Grinspan - Therapeutic advances in …, 2021 - journals.sagepub.com
Clostridioides difficile infection is a leading cause of healthcare-associated infections with
significant morbidity and mortality. For the past decade, the bulk of infection prevention and …
significant morbidity and mortality. For the past decade, the bulk of infection prevention and …
[HTML][HTML] Diagnostic stewardship in infectious diseases: a continuum of antimicrobial stewardship in the fight against antimicrobial resistance
Antimicrobial resistance (AMR) has been exacerbated by the inappropriate use of
diagnostics, leading to excessive prescription of antimicrobials, and is an imminent threat to …
diagnostics, leading to excessive prescription of antimicrobials, and is an imminent threat to …
Safety and tolerability of SER-109 as an investigational microbiome therapeutic in adults with recurrent Clostridioides difficile infection: a phase 3, open-label, single …
Importance A safe and effective treatment for recurrentClostridioides difficileinfection (CDI) is
urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …
urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …
Ultrasensitive and quantitative toxin measurement correlates with baseline severity, severe outcomes, and recurrence among hospitalized patients with Clostridioides …
CD Alonso, CP Kelly, KW Garey… - Clinical Infectious …, 2022 - academic.oup.com
Background Stool toxin concentrations may impact Clostridioides difficile infection (CDI)
severity and outcomes. We correlated fecal C difficile toxin concentrations, measured by an …
severity and outcomes. We correlated fecal C difficile toxin concentrations, measured by an …
Clinical outcomes of treated and untreated C. difficile PCR-positive/toxin-negative adult hospitalized patients: a quasi-experimental noninferiority study
CA Hogan, MM Hitchcock, S Frost… - Journal of Clinical …, 2022 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is routinely diagnosed by PCR, with or without toxin
enzyme immunoassay testing. The role of therapy for positive PCR and negative toxin …
enzyme immunoassay testing. The role of therapy for positive PCR and negative toxin …
Real-world evaluation of a two-step testing algorithm for Clostridioides difficile infection
MT Hecker, AH Son, P Zuccaro, J Conti… - Infection Control & …, 2023 - cambridge.org
During the 4 years after implementation of the 2-step Clostridioides difficile infection (CDI)
testing algorithm, 70% to 78% of patients with suspected CDI and a positive nucleic acid …
testing algorithm, 70% to 78% of patients with suspected CDI and a positive nucleic acid …
[HTML][HTML] Trends in and risk factors for recurrent Clostridioides difficile infection, New Haven County, Connecticut, USA, 2015–2020
CM Okafor, P Clogher, D Olson, L Niccolai… - Emerging Infectious …, 2023 - ncbi.nlm.nih.gov
Recurrent Clostridioides difficile infection (RCDI) causes an increased burden on the
healthcare system. We calculated RCDI incidence and identified factors associated with …
healthcare system. We calculated RCDI incidence and identified factors associated with …
Diagnostic stewardship in clinical microbiology, essential partner to antimicrobial stewardship
KV Sullivan - Clinical Chemistry, 2022 - academic.oup.com
Background Diagnostic stewardship is an important partner to antimicrobial stewardship.
Content Diagnostic stewardship focuses on ensuring correct diagnosis of infectious …
Content Diagnostic stewardship focuses on ensuring correct diagnosis of infectious …
Clostridioides difficile Infection: Diagnosis and Treatment Challenges
Clostridioides difficile is the most important cause of healthcare-associated diarrhea in the
United States. The high incidence and recurrence rates of C. difficile infection (CDI) …
United States. The high incidence and recurrence rates of C. difficile infection (CDI) …
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile
Clostridioides difficile produces toxins that damage the colonic epithelium, causing colitis.
Variation in disease severity is poorly understood and has been attributed to host factors …
Variation in disease severity is poorly understood and has been attributed to host factors …