Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection

CJ Lehmann, NP Dylla, M Odenwald, R Nayak… - Cell host & …, 2024 - cell.com
Metabolites produced by the intestinal microbiome modulate mucosal immune defenses and
optimize epithelial barrier function. Intestinal dysbiosis, including loss of intestinal …

Intestinal colonization resistance in the context of environmental, host, and microbial determinants

S Woelfel, MS Silva, B Stecher - Cell Host & Microbe, 2024 - cell.com
Microbial communities that colonize the human gastrointestinal (GI) tract defend against
pathogens through a mechanism known as colonization resistance (CR). Advances in …

Dietary-and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

AS Little, IT Younker, MS Schechter… - Nature …, 2024 - nature.com
Respiratory reductases enable microorganisms to use molecules present in anaerobic
ecosystems as energy-generating respiratory electron acceptors. Here we identify three …

Therapeutic manipulation of the microbiome in liver disease

G Parthasarathy, H Malhi, JS Bajaj - Hepatology, 2024 - journals.lww.com
Myriad associations between the microbiome and various facets of liver physiology and
pathology have been described in the literature. Building on descriptive and correlative …

A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice

LA Hesser, AA Puente, J Arnold, E Ionescu, A Mirmira… - Cell Host & Microbe, 2024 - cell.com
Depletion of beneficial microbes by modern lifestyle factors correlates with the rising
prevalence of food allergies. Re-introduction of allergy-protective bacteria may be an …

Gut microbiome profiles to exclude the diagnosis of hepatic encephalopathy in patients with cirrhosis

JS Bajaj, JG O'Leary, SS Jakab, A Fagan… - Gut …, 2024 - Taylor & Francis
Patients with cirrhosis who have cognitive complaints are presumed to have hepatic
encephalopathy (HE), which leads to unwarranted medications while ignoring the …

Unveiling the influence of a probiotic combination of Heyndrickxia coagulans and Lacticaseibacillus casei on healthy human gut microbiota using the TripleSHIME® …

E Goya-Jorge, I Gonza, P Bondue, G Druart… - Microbiological …, 2024 - Elsevier
Probiotics are host-friendly microorganisms that can have important health benefits in the
human gut microbiota as dietary supplements. Maintaining a healthy gut microbial balance …

A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease

HT Shen, YT Fang, WH Tsai, CH Chou… - Probiotics and …, 2024 - Springer
Chronic obstructive pulmonary disease (COPD) is the world's leading lung disease and
lacks effective and specific clinical strategies. Probiotics are increasingly used to support the …

Distinct patterns of microbiota and its function in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment and systemic inflammation

L Buttler, DA Velazquez Ramirez, A Tiede, AM Conradi… - medRxiv, 2024 - medrxiv.org
Background: Decompensated liver cirrhosis (dLC) is associated with a dysbalanced
microbiome, however, reasons for those observations and resulting consequences for …

A Caenorhabditis elegans based system for high-throughput functional phenotyping of human gut microbiota

A Ambat, V Thayyil Valappil, S Ghimire… - bioRxiv, 2024 - biorxiv.org
Bottoms-up approach of mono or poly colonizing microbes in germfree model is an
important tool for mechanistic understanding of human gut microbiota. However, doing this …