Proteostasis is a key driver of the pathogenesis in Apicomplexa
P Mitra, AS Deshmukh - Biochimica et Biophysica Acta (BBA)-Molecular …, 2024 - Elsevier
Proteostasis, including protein folding mediated by molecular chaperones, protein
degradation, and stress response pathways in organelles like ER (unfolded protein …
degradation, and stress response pathways in organelles like ER (unfolded protein …
Ubiquitin-proteasome system in Plasmodium: a potential antimalarial target to overcome resistance – a systematic review
AF Gonçalves, A Lima-Pinheiro, PE Ferreira - Frontiers in Medicine, 2024 - frontiersin.org
Background Malaria is a devasting parasitic disease that causes over half a million deaths
every year. The necessity for prompt and thorough antimalarial drug discovery and …
every year. The necessity for prompt and thorough antimalarial drug discovery and …
The proteasome as a drug target for treatment of parasitic diseases
LJ Liu, AJ O'Donoghue… - Advances in …, 2024 - pubmed.ncbi.nlm.nih.gov
The proteasome is a proteolytically active molecular machine comprising many different
protein subunits. It is essential for growth and survival in eukaryotic cells and has long been …
protein subunits. It is essential for growth and survival in eukaryotic cells and has long been …
Advances in protease inhibition-based chemotherapy: A decade of insights from Malaria Research
D Sojka, P Šnebergerová - Advances in parasitology, 2024 - pubmed.ncbi.nlm.nih.gov
Over the last decade, research on the most studied parasite, Plasmodium falciparum, has
disclosed significant findings in protease research. Detailed descriptions of the individual …
disclosed significant findings in protease research. Detailed descriptions of the individual …
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
Malaria remains a global health concern as drug resistance threatens treatment programs.
We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic …
We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic …