Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery
D Bald, C Villellas, P Lu, A Koul - MBio, 2017 - Am Soc Microbiol
Drug-resistant mycobacterial infections are a serious global health challenge, leading to
high mortality and socioeconomic burdens in developing countries worldwide. New …
high mortality and socioeconomic burdens in developing countries worldwide. New …
Tuberculosis—metabolism and respiration in the absence of growth
HIM Boshoff, CE Barry 3rd - Nature Reviews Microbiology, 2005 - nature.com
Human tuberculosis is a complex disease caused by bacterial populations that are located
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action
The differential transcriptional response of Mycobacterium tuberculosis to drugs and growth-
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …
Host cell-free growth of the Q fever bacterium Coxiella burnetii
A Omsland, DC Cockrell, D Howe… - Proceedings of the …, 2009 - National Acad Sciences
The inability to propagate obligate intracellular pathogens under axenic (host cell-free)
culture conditions imposes severe experimental constraints that have negatively impacted …
culture conditions imposes severe experimental constraints that have negatively impacted …
Bactericidal mode of action of bedaquiline
Objectives It is not fully understood why inhibiting ATP synthesis in Mycobacterium species
leads to death in non-replicating cells. We investigated the bactericidal mode of action of the …
leads to death in non-replicating cells. We investigated the bactericidal mode of action of the …
Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy
MI Voskuil, KC Visconti, GK Schoolnik - Tuberculosis, 2004 - Elsevier
The innate mechanisms used by Mycobacterium tuberculosis to persist during periods of
non-proliferation are central to understanding the physiology of the bacilli during latent …
non-proliferation are central to understanding the physiology of the bacilli during latent …
Energetics of respiration and oxidative phosphorylation in mycobacteria
The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments. A …
adapted to inhabit a wide range of intracellular and extracellular environments. A …
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans,
a neglected but devastating necrotic disease of subcutaneous tissue that is rampant …
a neglected but devastating necrotic disease of subcutaneous tissue that is rampant …
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis
The approval of bedaquiline has placed energy metabolism in the limelight as an attractive
target space for tuberculosis antibiotic development. While bedaquiline inhibits the …
target space for tuberculosis antibiotic development. While bedaquiline inhibits the …
Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration
Transcription profiling of genes encoding components of the respiratory chain and the ATP
synthesizing apparatus of Mycobacterium tuberculosis was conducted in vivo in the infected …
synthesizing apparatus of Mycobacterium tuberculosis was conducted in vivo in the infected …