The p53 tumor suppressor gene is inactivated in human tumors by several distinct
mechanisms. The best characterized inactivation mechanisms are:(i) gene mutation;(ii) p53 …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Here we report the isolation of a cDNA encoding a new p53‐associating protein. This new
protein has been called MDMX on the basis of its structural similarity to MDM2, which is …

Oral squamous carcinogenesis is a multistep process in which multiple genetic events occur
that alter the normal functions of oncogenes and tumour suppressor genes. This can result …

Although bladder cancer represents a serious health problem worldwide, relevant mouse
models for investigating disease progression or therapeutic targets have been lacking. We …

Cancer of the bladder shows divergent clinical behaviour following diagnosis and it has
been proposed that two major groups of tumours exist that develop via different molecular …

Bladder cancers are a leading cause of death from malignancy. Molecular markers might
predict disease progression and behaviour more accurately than the available prognostic …

Purpose: We provide a contemporary review of bladder tumor markers and summarize their
role as prognostic indicators. Materials and Methods: A comprehensive review of the …

In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes.
The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber …