The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
J Galon, HK Angell, D Bedognetti, FM Marincola - Immunity, 2013 - cell.com
Numerous analyses of large patient cohorts identified specific patterns of immune activation
associated with patient survival. We established these as the immune contexture …
associated with patient survival. We established these as the immune contexture …
Prognostic and predictive immune gene signatures in breast cancer
D Bedognetti, W Hendrickx, FM Marincola… - Current opinion in …, 2015 - journals.lww.com
This review examines our understanding of the molecular pathways associated with
intratumoral immune response, which represents a critical step for the implementation of …
intratumoral immune response, which represents a critical step for the implementation of …
Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis
Cancer immunotherapy is revolutionizing the clinical management of several tumors, but
has demonstrated limited activity in breast cancer. The development of more effective …
has demonstrated limited activity in breast cancer. The development of more effective …
CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
Background: Adoptive therapy with tumour-infiltrating lymphocytes (TILs) induces durable
complete responses (CR) in∼ 20% of patients with metastatic melanoma. The recruitment of …
complete responses (CR) in∼ 20% of patients with metastatic melanoma. The recruitment of …
Immunogenic subtypes of breast cancer delineated by gene classifiers of immune responsiveness
The abundance and functional orientation of tumor-infiltrating lymphocytes in breast cancer
is associated with distant metastasis-free survival, yet how this association is influenced by …
is associated with distant metastasis-free survival, yet how this association is influenced by …
Immune oncology, immune responsiveness and the theory of everything
Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic
and long lasting but occur in a subset of tumors and are largely dependent upon the pre …
and long lasting but occur in a subset of tumors and are largely dependent upon the pre …
The immunologic constant of rejection classification refines the prognostic value of conventional prognostic signatures in breast cancer
Background The immunologic constant of rejection (ICR) is a broad phenomenon of Th-1
immunity-mediated, tissue-specific destruction. Methods We tested the prognostic value of a …
immunity-mediated, tissue-specific destruction. Methods We tested the prognostic value of a …
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk
EP Salerno, D Bedognetti, IS Mauldin… - …, 2016 - Taylor & Francis
We have identified eight genes whose expression in human melanoma metastases and
ovarian cancers is associated with a lack of Th1 immune signatures. They encode …
ovarian cancers is associated with a lack of Th1 immune signatures. They encode …
Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?
Abstract T helper (Th) 17 cells, a distinct subset of Th lymphocytes, are known for their
prominent interleukin (IL)-17 production and other pro-inflammatory cytokines. These cells …
prominent interleukin (IL)-17 production and other pro-inflammatory cytokines. These cells …
Th17 cells paradoxical roles in melanoma and potential application in immunotherapy
C Chen, FH Gao - Frontiers in immunology, 2019 - frontiersin.org
The progressive infiltration of immune cells is associated with the progression of melanoma.
Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor …
Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor …