Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

AL Cheng, C Hsu, SL Chan, SP Choo, M Kudo - Journal of hepatology, 2020 - Elsevier
Immune checkpoint inhibitor (ICI) therapy targeting anti-programmed cell death-1 (anti-PD-
1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at …

The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease

M Eslam, SK Sarin, VWS Wong, JG Fan… - Hepatology …, 2020 - Springer
Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver
disease and affects nearly a quarter of the global population. The objective of this work was …

Hepatic arterial infusion chemotherapy versus transarterial chemoembolization for unresectable hepatocellular carcinoma: a systematic review with meta-analysis

T Si, Z Huang, SE Khorsandi, Y Ma… - … in Bioengineering and …, 2022 - frontiersin.org
Background: Interest has revived in the use of hepatic arterial infusion chemotherapy (HAIC)
for intermediate-advanced hepatocellular carcinoma (HCC) while transarterial …

Outcome of no-touch radiofrequency ablation for small hepatocellular carcinoma: a multicenter clinical trial

DH Lee, MW Lee, PN Kim, YJ Lee, HS Park, JM Lee - Radiology, 2021 - pubs.rsna.org
Background Recently introduced no-touch radiofrequency ablation (RFA) of hepatocellular
carcinoma (HCC) has the potential to improve local tumor control. Purpose To evaluate …

Serum exosomal microRNA, miR-10b-5p, as a potential diagnostic biomarker for early-stage hepatocellular carcinoma

HJ Cho, JW Eun, GO Baek, CW Seo, HR Ahn… - Journal of Clinical …, 2020 - mdpi.com
Exosomal microRNAs (exo-miRs) have been promising cancer biomarkers. MiRs in
hepatocellular carcinoma (HCC) cell-derived exosomes (HEX) were analyzed to identify …

Laparoscopic liver resection versus percutaneous radiofrequency ablation for small single nodular hepatocellular carcinoma: comparison of treatment outcomes

DH Lee, JW Kim, JM Lee, JM Kim, MW Lee, H Rhim… - Liver cancer, 2021 - karger.com
Background: Treatment outcomes of laparoscopic liver resection (LLR) and percutaneous
radiofrequency ablation (p-RFA) for small single hepatocellular carcinomas (HCCs) have …

Prognostic significance of cachexia index in patients with advanced hepatocellular carcinoma treated with systemic chemotherapy

MJ Goh, W Kang, WK Jeong, DH Sinn, GY Gwak… - Scientific Reports, 2022 - nature.com
Cancer cachexia affects quality of life, response to chemotherapy, and survival in many
advanced cancer patients. The aim of this study was to evaluate the prognostic value of …

Noncontrast MRI for hepatocellular carcinoma detection: a systematic review and meta-analysis–a potential surveillance tool?

MV Chan, YR Huo, N Trieu, A Mitchelle… - Clinical …, 2022 - Elsevier
Background and aims This meta-analysis investigates the diagnostic performance of non-
contrast magnetic resonance imaging (MRI) for the detection of hepatocellular carcinoma …

Paradigm shift in the treatment options of hepatocellular carcinoma

TH Su, SJ Hsu, JH Kao - Liver International, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC) is prevalent worldwide with suboptimal therapeutic
outcomes. The advancement of therapeutic options and the development of new systemic …

Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab

N Kim, JI Yu, HC Park, GS Yoo, C Choi… - Cancer Immunology …, 2021 - Springer
Background We investigated the combined effects of sarcopenia and inflammation on
outcomes in patients with HCC treated with nivolumab. Materials and Methods We reviewed …