Abstract Oxindole (indoline-2, 3-dione) has been utilized to a great extent in heterocyclic
scaffold syntheses as a futuristic medication and is considered a prominent building block …

Plants synthesize tens of thousands of bioactive nitrogen-containing compounds called
alkaloids, including some clinically important drugs in modern medicine. The discovery of …

Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-
pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition …

Kratom is widely consumed in the United States for self-treatment of pain and opioid
withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid …

Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a
heterocyclic moiety. These compounds display an extensive range of biological activities …

Spirophyllines A–D (1–4), four new spirooxindole alkaloids all characterized by the spiro
[pyrrolidin-3, 3′-oxindole] core and a rare isoxazolidine ring, were isolated from Uncaria …

Tetracyclic oxindole alkaloids (TOAs), main active ingredients of Uncaria rhynchophylla
(UR), has inspired the interest of pharmacologists and chemists because of its great …

Cortex Uncariae is the stem of Uncaria tomentosa plant, which belongs to the family
Rubiaceae. Cat's thorn and unha de gato are the famous names of Cortex Uncariae …

To explore candidate pesticides from non-food bioactive products, twenty-five new matrine-
type alkaloid analogs, 15-chloro-18-(acyl) oximinylmatrines (6a–6y), were semi-synthesized …

Cat's claw (Uncaria tomentosa (Willd. ex Schults) DC.), a plant that is exceptionally rich in
phytochemicals, has been used for centuries by the indigenous people of South and Central …