Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology

MM Rahman, C Lendel - Molecular Neurodegeneration, 2021 - Springer
Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host

B Singh, C Fleury, F Jalalvand… - FEMS microbiology …, 2012 - academic.oup.com
Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Complement in breast milk modifies offspring gut microbiota to promote infant health

D Xu, S Zhou, Y Liu, AL Scott, J Yang, F Wan - Cell, 2024 - cell.com
Breastfeeding offers demonstrable benefits to newborns and infants by providing
nourishment and immune protection and by shaping the gut commensal microbiota …

Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection

P Castro-Córdova, P Mora-Uribe… - Nature …, 2021 - nature.com
Clostridioides difficile spores produced during infection are important for the recurrence of
the disease. Here, we show that C. difficile spores gain entry into the intestinal mucosa via …

Borrelia miyamotoi: A Comprehensive Review

DW Cleveland, CC Anderson, CA Brissette - Pathogens, 2023 - mdpi.com
Borrelia miyamotoi is an emerging tick-borne pathogen in the Northern Hemisphere and is
the causative agent of Borrelia miyamotoi disease (BMD). Borrelia miyamotoi is vectored by …

[HTML][HTML] Offense and defense: microbial membrane vesicles play both ways

IA MacDonald, MJ Kuehn - Research in microbiology, 2012 - Elsevier
Microbes have evolved over millennia to become adapted and specialized to the
environments that they occupy. These environments may include water or soil, extreme …

Mechanisms of host manipulation by Neisseria gonorrhoeae

E Walker, S van Niekerk, K Hanning, W Kelton… - Frontiers in …, 2023 - frontiersin.org
Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in
humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an …

Bacteria under stress by complement and coagulation

ETM Berends, A Kuipers, MM Ravesloot… - FEMS microbiology …, 2014 - academic.oup.com
The complement and coagulation systems are two related protein cascades in plasma that
serve important roles in host defense and hemostasis, respectively. Complement activation …

Human complement control and complement evasion by pathogenic microbes–tipping the balance

PF Zipfel, T Hallstroem, K Riesbeck - Molecular immunology, 2013 - Elsevier
Complement is a central homeotic system of mammals and represents the first defense line
of innate immunity. The human complement system is aimed to maintain homeostasis by …

Bacterial excretion of cytoplasmic proteins (ECP): occurrence, mechanism, and function

P Ebner, F Götz - Trends in microbiology, 2019 - cell.com
The excretion of cytoplasmic and signal-peptide-less proteins (ECP) by microorganisms and
eukaryotes remains a fascinating topic. In principle, it appears to be a waste of energy …