The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …

More than eight hundred million people worldwide have chronic liver disease, with two
million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards …

Background Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or
trauma and usually leads to esthetic disfiguration and functionary impairment for patients …

Background & Aims Autophagy plays a crucial role in hepatic homeostasis and its
deregulation has been associated with chronic liver disease. However, the effect of …

For studying cellular communications ex-vivo, a two-dimensional (2D) cell culture model is
currently used as the “gold standard”. 2D culture models are also widely used in the study of …

Activation of hepatic macrophages represents the critical driving force to promote cholestatic
liver injury. Exosomes, as important small extracellular vesicles released by almost all types …

Nonalcoholic fatty liver disease (NAFLD) is currently one of most common forms of chronic
liver disease globally. NAFLD represents a wide spectrum of liver involvement from …

Liver disease is responsible for approximately 1.2 million global deaths per year, which
account for 3.5% of all deaths worldwide.[1] Acute liver injury is often reversible, while …

Background and Aims Alcoholic hepatitis (AH) is diagnosed by clinical criteria, although
several objective scores facilitate risk stratification. Extracellular vesicles (EVs) have …

Trauma remains a leading cause of morbidity and mortality. Polytraumatized patients need a
precise, early diagnosis to avoid complications such as multiorgan failure or sepsis …