Leprosy: clinical and immunopathological characteristics

LAR Froes, MN Sotto, MAB Trindade - Anais Brasileiros de …, 2022 - SciELO Brasil
Leprosy, a disease caused by Mycobacterium leprae, has polymorphic neurocutaneous
manifestations strongly correlated with the host immune response. Peripheral neural …

Viral co‐infections in leprosy: a scoping review

LAR Fróes Jr, TS Toma, RE Poderoso… - International Journal …, 2023 - Wiley Online Library
Context The most reported viral co‐infections in leprosy are human immunodeficiency virus
(HIV), human T‐cell lymphotropic virus (HTLV), hepatitis B virus (HBV), hepatitis C virus …

Presenting symptoms of leprosy at diagnosis: Clinical evidence from a cross-sectional, population-based study

X Chen, S Zha, TJ Shui - PLoS Neglected Tropical Diseases, 2021 - journals.plos.org
Background Leprosy is associated with different dermatologic and neurologic manifestations
within a wide clinical spectrum, causing a great diagnostic challenge. Therefore, we aimed …

Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

BH Pogostin, HY Marina, AR Azares, EM Euliano… - Biomaterials …, 2022 - pubs.rsc.org
Adjuvants play a critical role in enhancing vaccine efficacy; however, there is a need to
develop new immunomodulatory compounds to address emerging pathogens and to …

Association between SNPs in microRNAs and microRNAs-machinery genes with susceptibility of leprosy in the amazon population

MNS da Silva, DF da Veiga Borges Leal… - International Journal of …, 2022 - mdpi.com
Leprosy is a chronic neurodermatological disease caused by the bacillus Mycobacterium
leprae. Recent studies show that SNPs in genes related to miRNAs have been associated …

Psoriasis and leprosy: an arcane relationship

G Ge, J Shang, T Gan, Z Chen, C Pan… - Journal of …, 2023 - Taylor & Francis
Purpose Psoriasis (Ps) and leprosy are chronic inflammatory skin disorders, characterised
by enhanced innate and adaptive immunity. Ps and leprosy rarely coexist. The molecular …

In silico designing of a recombinant multi-epitope antigen for leprosy diagnosis

MR Lemes, TCV Rodrigues, AK Jaiswal… - Journal of Genetic …, 2022 - Springer
Background Leprosy is caused by Mycobacterium leprae and Mycobacterium lepromatosis.
Most of the affected population lives in low-income countries and may take up to 10 years to …

An update on leprosy immunopathogenesis: systematic review

MJA Silva, CS Silva, TP Brasil, AK Alves… - Frontiers in …, 2024 - frontiersin.org
Introduction Leprosy is a chronic infectious condition and the main cause of neuropathy that
occurs brought on by M. leprae. It is known that the biological characteristics of the human …

[HTML][HTML] Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

S Wilkin, LT Lanigan, N Montes, M Sharma, C Avanzi… - Iscience, 2024 - cell.com
This study investigates the efficacy of proteomic analysis of human remains to identify active
infections in the past through the detection of pathogens and the host response to infection …

Potential role of CXCL10 in monitoring response to treatment in leprosy patients

H Ferreira, MA Mendes… - Frontiers in …, 2021 - frontiersin.org
The treatment of multibacillary cases of leprosy with multidrug therapy (MDT) comprises 12
doses of a combination of rifampicin, dapsone and clofazimine. Previous studies have …