Novel cytocompatible chitosan Schiff base derivative as a potent antibacterial, antidiabetic, and anticancer agent

AM Omer, AS Eltaweil, EM El-Fakharany… - Arabian Journal for …, 2023 - Springer
This study intends to develop a novel bioactive chitosan Schiff base (CTS-SB) derivative via
coupling of chitosan (CTS) with 4-((5, 5-dimethyl-3-oxocyclohex-1-en-1-yl) amino) benzene …

Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors

MS Ayoup, A Ammar, H Abdel-Hamid, A Amer… - Bioorganic …, 2024 - Elsevier
Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2)
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …

Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal …

SK Sahoo, S Maddipatla, SNR Gajula… - Bioorganic & Medicinal …, 2022 - Elsevier
Ever increasing drug resistance has become an impeding threat that continues to hamper
effective tackling of otherwise treatable tuberculosis (TB). Such dismal situation necessitates …

Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

P Das, N Devi, N Gaur, S Goswami, D Dutta… - Scientific Reports, 2023 - nature.com
In this work, five acrylonitrile adducts were screened for antibacterial activity against Gram-
positive Bacillus subtilis, Microbial Type Culture Collection and Gene Bank (MTCC 1305) …

Design and Synthesis of Quinoxaline Hybrids as Modulators of HIF-1a, VEGF, and p21 for Halting Colorectal Cancer

MS Ayoup, AR Rabee, H Abdel-Hamid, A Amer… - ACS …, 2024 - ACS Publications
A library of 16 3-benzyl-N 1-substituted quinoxalin-2-ones was synthesized as N 1-
substituted quinoxalines and quinoxaline-triazole hybrids via click reaction. These …

Intramolecular Hydrogen Bonding Effect on the Electron-Transfer Thermodynamics of a Series of o-Nitrobenzyl Alcohol Derivatives

Y Enriquez-Izazaga, JA Rodriguez-Nuñez… - The Journal of …, 2023 - ACS Publications
From thermoelectrochemical experiments and electronic structure calculations of a series of
nitrobenzyl alcohol derivatives, the effect of intramolecular hydrogen bonding (IHB) on the …

A green electrochemical method for the synthesis of new sulfonamide and disulfonamide derivatives based on the oxidation of phenylhydrazine derivatives and …

HHS Arkwazee, N Mohamadighader… - Journal of The …, 2022 - iopscience.iop.org
Electrochemical synthesis of some new sulfonamide and disulfonamide derivatives was
carried out via the air-assisted electrochemical oxidation of phenylhydrazine (PhD) and 4 …

Hydrazone analogs as DNA gyrase inhibitors and antioxidant agents: Structure-activity relationship and pharmacophore modeling

O Dammene Debbih, W Mazouz, O Benslama… - Journal of Chemical …, 2024 - Springer
In this paper, we report the synthesis and the structure–activity relationship study of three
hydrazone analogs; the Schiff base hydrazone SBH and 2, 4-dinitrophenylhydrazones H1 & …

Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation

S Pelliccia, AI Alfano, BR Gomes Da Assunção… - Frontiers in …, 2023 - frontiersin.org
The [1, 2, 3]-triazolo [1, 5-a] quinoxalin-4 (5 H)-one scaffold and its analogues triazole-fused
heterocyclic compounds are relevant structural templates in both natural and synthetic …

Semisynthetic Derivatives of Sissotrin Isolated from Trifolium baccarinii Chiov. (Fabaceae) and Evaluation of Their Antibacterial Activities

DLF Tsamo, CN Tagousop, AJN Dongmo… - Advances in Biological …, 2024 - hal.science
Starting from sissotrin (1), a natural isoflavonoid isolated from Trifolium baccarinii
(Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known …