[HTML][HTML] Apolipoprotein E in lipid metabolism and neurodegenerative disease

LG Yang, ZM March, RA Stephenson… - Trends in Endocrinology & …, 2023 - cell.com
Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Systematic review of dementia prevalence and incidence in United States race/ethnic populations

KM Mehta, GW Yeo - Alzheimer's & Dementia, 2017 - Elsevier
Objective To identify incidence and prevalence of dementia in racial and ethnic populations
in the United States. Methods A systematic review of literature. Results A total of 1215 …

[HTML][HTML] Alzheimer mechanisms and therapeutic strategies

Y Huang, L Mucke - Cell, 2012 - cell.com
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

PM Thompson, JL Stein, SE Medland, DP Hibar… - Brain imaging and …, 2014 - Springer
Abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Consortium is a collaborative network of researchers working together on a range of large …

Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease

JC Lambert, A Ramirez, B Grenier-Boley… - Molecular …, 2023 - nature.com
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4, and the risk of late-onset Alzheimer disease in African Americans

C Reitz, G Jun, A Naj, R Rajbhandary, BN Vardarajan… - Jama, 2013 - jamanetwork.com
Importance Genetic variants associated with susceptibility to late-onset Alzheimer disease
are known for individuals of European ancestry, but whether the same or different variants …

Alzheimer's disease in African Americans: risk factors and challenges for the future

LL Barnes, DA Bennett - Health affairs, 2014 - healthaffairs.org
As the US elderly population continues to expand rapidly, Alzheimer's disease poses a
major and increasing public health challenge, and older African Americans may be …

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

CA Rietveld, SE Medland, J Derringer, J Yang, T Esko… - science, 2013 - science.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study

K Yaffe, C Falvey, TB Harris, A Newman, S Satterfield… - Bmj, 2013 - bmj.com
Objective To examine whether observed differences in dementia rates between black and
white older people living in the community could be explained by measures of …

Recent progress in Alzheimer's disease research, part 2: genetics and epidemiology

M Robinson, BY Lee, FT Hane - Journal of Alzheimer's …, 2017 - content.iospress.com
This is the second part of a three-part review series reviewing the most important advances
in Alzheimer's disease (AD) research since 2010. This review covers the latest research on …