A new and powerful electrochemical sensing platform based on MWCNTs@ Fe3O4@ CuAl2O4 for the determination of the anticancer agent Alpelisib in bulk and …
Alpelisib, an anti-cancer drug with great potential, targets the phosphoinositide 3-kinase
(PI3K) pathway, which is commonly dysregulated in various cancer types. Accurate and …
(PI3K) pathway, which is commonly dysregulated in various cancer types. Accurate and …
Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@ RGH nanocomposite material
A novel electrochemical sensor based on LaNiO 3/gC 3 N 4@ RGH nanocomposite material
was developed to simultaneously determine Ribociclib (RIBO) and Alpelisib (ALPE) …
was developed to simultaneously determine Ribociclib (RIBO) and Alpelisib (ALPE) …
Repurposing alpelisib, an anti‐cancer drug, for the treatment of severe TIE2‐mutated venous malformations: preliminary pharmacokinetics and pharmacodynamic …
Extensive venous malformations involving limbs severely impact quality of life, mostly due to
chronic pain and functional limitations. But patients can also display coagulopathy with …
chronic pain and functional limitations. But patients can also display coagulopathy with …
Detection and quantitation of adulterated paprika samples using second-order HPLC-FLD fingerprints and chemometrics
X Sun, M Zhang, P Wang, J Chen, S Yang, P Luo… - Foods, 2022 - mdpi.com
Paprika is a widely consumed spice in the world and its authentication has gained interest
considering the increase in adulteration cases in recent years. In this study, second-order …
considering the increase in adulteration cases in recent years. In this study, second-order …
Factors determining the oral absorption and systemic disposition of zeaxanthin in rats: in vitro, in situ, and in vivo evaluations
Context Zeaxanthin is a yellow‑coloured dietary carotenoid widely recognized as an
essential component of the macula. It exerts blue light filtering and antioxidant activities …
essential component of the macula. It exerts blue light filtering and antioxidant activities …
Determination of Leuprolide–Fatty Acid Conjugate in Rat Plasma Using LC-MS/MS and Its Pharmacokinetics after Subcutaneous Administration in Rats
Leuprolide is a synthetic nonapeptide drug (pyroGlu-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro-
NHEt) that acts as a gonadotropin-releasing hormone agonist. The continuous …
NHEt) that acts as a gonadotropin-releasing hormone agonist. The continuous …
A simple and sensitive HPLC-FL method for bioanalysis of velpatasvir, a novel hepatitis C virus NS5A inhibitor, in rat plasma: Investigation of factors determining its …
Velpatasvir is a novel inhibitor of hepatitis C virus nonstructural protein 5A that received US
Food and Drug Administration approval for the treatment of patients with chronic hepatitis C …
Food and Drug Administration approval for the treatment of patients with chronic hepatitis C …
Characterization of Alpelisib in rat plasma by a newly developed UPLC-MS/MS method: application to a drug-drug interaction study
Q Wang, X Lan, Z Zhao, X Su, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Alpelisib, an oral selective and small-molecule phosphoinositide 3-kinase inhibitor, was
lately approved in the United States to treat breast cancer. A sensitive method to quantify …
lately approved in the United States to treat breast cancer. A sensitive method to quantify …
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations
Abstract Alizarin (1, 2‐dihydroxyanthraquinone) is an anthraquinone reddish dye widely
used for painting and textile dyeing. As the biological activity of alizarin has recently …
used for painting and textile dyeing. As the biological activity of alizarin has recently …
Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study
Alpelisib is the first alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor indicated for
the treatment of hormone receptor-positive, human epidermal growth factor receptor 2 …
the treatment of hormone receptor-positive, human epidermal growth factor receptor 2 …