[HTML][HTML] Circulating RNAs in prostate cancer patients

V Mugoni, Y Ciani, C Nardella, F Demichelis - Cancer letters, 2022 - Elsevier
Growing bodies of evidence have demonstrated that the identification of prostate cancer
(PCa) biomarkers in the patients' blood and urine may remarkably improve PCa diagnosis …

The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

NL Yuwono, K Warton, CE Ford - Elife, 2021 - elifesciences.org
Research and clinical use of circulating cell-free DNA (cirDNA) is expanding rapidly;
however, there remain large gaps in our understanding of the influence of lifestyle and …

Current challenges and best practices for cell-free long RNA biomarker discovery

L Cabús, J Lagarde, J Curado, E Lizano… - Biomarker …, 2022 - Springer
The analysis of biomarkers in biological fluids, also known as liquid biopsies, is seen with
great potential to diagnose complex diseases such as cancer with a high sensitivity and …

Plasma cell‐free DNA methylation analysis for ovarian cancer detection: Analysis of samples from a case‐control study and an ovarian cancer screening trial

C Herzog, A Jones, I Evans, D Reisel… - … Journal of Cancer, 2024 - Wiley Online Library
Abstract Analysis of cell‐free DNA methylation (cfDNAme), alone or combined with CA125,
could help to detect ovarian cancers earlier and may reduce mortality. We assessed …

[HTML][HTML] A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics

C Grätz, M Schuster, F Brandes, AS Meidert… - Molecular Aspects of …, 2024 - Elsevier
Extracellular vesicles are shed by every cell type and can be found in any biofluid. They
contain different molecules that can be utilized as biomarkers, including several RNA …

Integrated analysis of circulating cell free nucleic acids for cancer genotyping and immune phenotyping of tumor microenvironment

M Chaddha, H Rai, R Gupta, D Thakral - Frontiers in Genetics, 2023 - frontiersin.org
The circulating cell-free nucleic acids (ccfNAs) consist of a heterogenous cocktail of both
single (ssNA) and double-stranded (dsNA) nucleic acids. These ccfNAs are secreted into the …

Age-related changes in antigen-specific natural antibodies are influenced by sex

SE Webster, NL Tsuji, MJ Clemente… - Frontiers in …, 2023 - frontiersin.org
Introduction Natural antibody (NAb) derived from CD5+ B-1 cells maintains tissue
homeostasis, controls inflammation, aids in establishing long-term protective responses …

Low fetal fraction in obese women at first trimester cell‐free DNA based prenatal screening is not accompanied by differences in total cell‐free DNA

R Shree, TR Kolarova, HJ MacKinnon… - Prenatal …, 2021 - Wiley Online Library
Objective Reasons for first trimester noninvasive prenatal screening (NIPS) test failure in
obese women remain elusive. As dilution from maternal sources may be explanatory, we …

Quantitative Analysis of Cell-Free RNA at Attomolar Level Using CRISPR/Cas Digital Imaging Platform

Y Li, F Quan, Y Wu, Y Zhang, R Xu, Y Wu… - Analytical …, 2024 - ACS Publications
Quantitative analysis of cell-free RNA (cfRNA) in plasma sample can be used for screening,
diagnosing, and prognosticating of multiple diseases. Here, we report a quantitative …

A review on cell-Free RNA Profiling: insights into metabolic diseases and predictive value for bariatric surgery outcomes

M Mareboina, E Deng, I Mouratidis, NS Yee… - Molecular …, 2024 - Elsevier
The advent of liquid biopsies presents a novel, minimally invasive methodology for the
detection of disease biomarkers, offering a significant advantage over traditional biopsy …