Testicular germ cell tumours are at the crossroads of developmental and neoplastic
processes. Their cause has not been fully elucidated but differences in incidences suggest …

Testicular germ cell tumors (TGCT) are the most common malignancy in young men. While
most TGCT are potentially curable, approximately 5% of patients with TGCT may develop …

Paradoxically, during early tumor development in many cancer types, TGF-β acts as a tumor
suppressor, whereas in the advanced stages of these cancers, increased TGF-β expression …

Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have
synergistic roles in cellular systems and their disruption may cause diseases including …

Ushiku T, Shinozaki‐Ushiku A, Maeda D, Morita S & Fukayama M (2012) Histopathology
Distinct expression pattern of claudin‐6, a primitive phenotypic tight junction molecule, in …

This review focuses on the molecular characteristics and development of rare malignant
ovarian germ cell tumors (mOGCTs). We provide an overview of the genomic aberrations …

In utero exposure to bisphenol A (BPA) increases mammary cancer susceptibility in
offspring. High-fat diet is widely believed to be a risk factor of breast cancer. The objective of …

Despite their clinicopathologic heterogeneity, malignant germ cell tumors (GCT) share
molecular abnormalities that are likely to be functionally important. In this study, we …

The pathways of gametogenesis encompass elaborate cellular specialization accompanied
by precise partitioning of the genome content in order to produce fully matured spermatozoa …

This concise review summarises tissue and serum markers useful for differential diagnosis
of germ cell tumours (GCT), with focus on the most common testicular GCT (TGCT). GCT are …