Little is known about the pathophysiology of pelvic organ prolapse (POP). In 1996, Jackson
presented a hypothesis on pelvic floor connective tissue that tried to explain the …

Objective: Genital prolapse is frequent in postmenopausal women; it describes the loss of
support to the pelvic organs, resulting in a herniation of these into the vaginal channel. This …

Purpose: We describe current knowledge about collagen/elastin and extracellular matrix
metabolism in the genitourinary tract with special emphasis on stress urinary incontinence …

Introduction and hypothesis The pathophysiology of pelvic organ prolapse (POP) is
incompletely understood. The purpose of this study is to describe the current knowledge …

Female pelvic organ prolapse is a common condition that is said to be multifactorial in
aetiology. While a number of risk factors such as vaginal childbirth, obesity and ageing are …

Introduction and hypothesis There is clear evidence of the presence of estradiol receptors
(ERs) in the female lower urinary and genital tract. Furthermore, it is a fact that estrogen …

Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support
tissues, and often by subsequent prolapse of the bladder outside the body, ie cystocele. The …

OBJECTIVES To compare elastin expression and elastic fibre width in the anterior vaginal
wall of postmenopausal women with and with no bladder prolapse. PATIENTS AND …

Background Pelvic floor dysfunction (PFD) is a group of clinical conditions including stress
urinary incontinence (SUI) and pelvic organ prolapse (POP). The abnormality of collagen …

The aim of this study is to characterize and model the damage process in the anterior rectus
abdominal aponeurosis (anterior rectus sheath) undergoing finite deformations. The …