Conventional external-beam radiation therapy is dedicated to the treatment of localized
disease, whereas radioimmunotherapy represents an innovative tool for the treatment of …

Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …

High atomic number material, such as gold, may be used in conjunction with radiation to
provide dose enhancement in tumors. In the current study, we investigated the dose …

Within three decades, anti-angiogenic therapy has rapidly evolved into an integral
component of current standard anti-cancer treatment. Anti-angiogenic therapy has fulfilled a …

Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …

Background: An effective cancer therapeutic must selectively target tumours with minimal
systemic toxicity. Expression of a cytotoxic protein using Salmonella typhimurium would …

Synthetic alkylphospholipids (ALPs), such as edelfosine, miltefosine, perifosine,
erucylphosphocholine and erufosine, represent a relatively new class of structurally related …

Synthetic anticancer alkylphospholipids (APLs), such as edelfosine, miltefosine and
perifosine, are a group of structurally related lipids that act on cellular membranes rather …

Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and
accounts for approximately 3% of adult malignancies. The RCC incidence rate increases …

We have previously shown that activation of the acid sphingomyelinase (ASM), the release
of ceramide and the formation of ceramide-enriched membrane domains are central for the …