The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

Obesity is a chronic illness associated with several metabolic derangements and
comorbidities (ie, insulin resistance, leptin resistance, diabetes, etc.) and often leads to …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback
actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are …

Polycystic ovary syndrome (PCOS) is the most common endocrinopathies affecting the early
reproductive age in women, whose pathophysiology perplexes many researchers till today …

The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of
reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …