[HTML][HTML] Red blood cell transfusion policy: a critical literature review

M Franchini, G Marano, C Mengoli, S Pupella… - Blood …, 2017 - ncbi.nlm.nih.gov
The issue of the most appropriate red blood cell transfusion policy has been addressed by a
number of randomised controlled trials, conducted over the last decades, comparing the …

Real age: red blood cell aging during storage

CG Koch, AI Duncan, P Figueroa, L Dai… - The Annals of thoracic …, 2019 - Elsevier
Background During cold storage, some red blood cell (RBC) units age more rapidly than
others. Yet, the Food and Drug Administration has set a uniform storage limit of 42 days …

Metabolic linkage and correlations to storage capacity in erythrocytes from glucose 6-phosphate dehydrogenase-deficient donors

JA Reisz, VL Tzounakas, T Nemkov… - Frontiers in …, 2018 - frontiersin.org
Objective In glucose 6-phosphate dehydrogenase (G6PD) deficiency, decreased NADPH
regeneration in the pentose phosphate pathway and subnormal levels of reduced …

Red blood cell transfusion in surgical cancer patients: Targets, risks, mechanistic understanding and further therapeutic opportunities

VL Tzounakas, J Seghatchian, E Grouzi… - … and Apheresis Science, 2017 - Elsevier
Anemia is present in more than half of cancer patients and appears to be an independent
prognostic factor of short-and long-term adverse outcomes. It increases in the advanced …

The post-storage performance of RBCs from beta-thalassemia trait donors is related to their storability profile

AT Anastasiadi, EC Paronis, VZ Arvaniti… - International Journal of …, 2021 - mdpi.com
Blood donors with beta-thalassemia traits (βThal+) have proven to be good “storers”, since
their stored RBCs are resistant to lysis and resilient against oxidative/proteotoxic stress. To …

Modelling of red blood cell morphological and deformability changes during in-vitro storage

N Geekiyanage, E Sauret, S Saha, R Flower, YT Gu - Applied Sciences, 2020 - mdpi.com
Featured Application Red blood cell (RBC) storage lesion is a critical issue facing
transfusion treatments, and significant changes in RBC morphology and deformability are …

Erythrocyte-based drug delivery in transfusion medicine: wandering questions seeking answers

VL Tzounakas, DG Karadimas, IS Papassideri… - … and Apheresis Science, 2017 - Elsevier
Red blood cells (RBCs) represent the most commonly used and best-studied natural carriers
in the history of drug delivery. Their abundance and long circulation half-life, their great …

Restoration of physiological levels of uric acid and ascorbic acid reroutes the metabolism of stored red blood cells

M Bardyn, J Chen, M Dussiot, D Crettaz, L Schmid… - Metabolites, 2020 - mdpi.com
After blood donation, the red blood cells (RBCs) for transfusion are generally isolated by
centrifugation and then filtrated and supplemented with additive solution. The consecutive …

Red cell transfusion in paediatric patients with thalassaemia and sickle cell disease: current status, challenges and perspectives

VL Tzounakas, SI Valsami, AG Kriebardis… - … and apheresis science, 2018 - Elsevier
Notwithstanding the high safety level of the currently available blood for transfusion and the
decreasing frequency of transfusion-related complications, administration of labile blood …

基于代谢组学的红细胞贮存损伤相关研究新进展

王欢, 徐方, 郭建荣 - 临床输血与检验, 2022 - lcsxyjy.com
组学技术是通过超高通量定量跟踪标记底物的实验研究方法, 从整体角度出发分析人类组织器官
功能和代谢的状态. 代谢组学定量研究了在外界不同刺激情况下红细胞代谢物的生理和病理变化 …