Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis

TS Kang, D Georgieva, N Genov… - The FEBS …, 2011 - Wiley Online Library
Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Haemostatically active proteins in snake venoms

T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …

Antitumoral activity of snake venom proteins: new trends in cancer therapy

LA Calderon, JC Sobrinho, KD Zaqueo… - BioMed research …, 2014 - Wiley Online Library
For more than half a century, cytotoxic agents have been investigated as a possible
treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues …

Snake venom L‐amino acid oxidases: Trends in pharmacology and biochemistry

LFM Izidoro, JC Sobrinho, MM Mendes… - BioMed research …, 2014 - Wiley Online Library
L‐amino acid oxidases are enzymes found in several organisms, including venoms of
snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is …

Protein complexes in snake venom

R Doley, RM Kini - Cellular and molecular life sciences, 2009 - Springer
Snake venom contains mixture of bioactive proteins and polypeptides. Most of these
proteins and polypeptides exist as monomers, but some of them form complexes in the …

Past decade study of snake venom L-amino acid oxidase

C Guo, S Liu, Y Yao, Q Zhang, MZ Sun - Toxicon, 2012 - Elsevier
As one of the major protein (enzyme) components of snake venom (SV), l-amino acid
oxidase (LAAO) plays an important role in the toxicities and biological activities for SV …

Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

JS Cavalcante, DEG de Almeida… - International Journal of …, 2023 - mdpi.com
Snakebite envenoming represents a major health problem in tropical and subtropical
countries. Considering the elevated number of accidents and high morbidity and mortality …

[HTML][HTML] Snake venom L-amino acid oxidases: an overview on their antitumor effects

TR Costa, SM Burin, DL Menaldo… - Journal of Venomous …, 2014 - SciELO Brasil
The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and
have been widely studied due to their widespread presence and various effects, such as …

The role of platelets in hemostasis and the effects of snake venom toxins on platelet function

MR de Queiroz, BB de Sousa, DF da Cunha Pereira… - Toxicon, 2017 - Elsevier
The human body has a set of physiological processes, known as hemostasis, which keeps
the blood fluid and free of clots in normal vessels; in the case of vascular injury, this process …