Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

Circadian control of cell division is well established in diverse organisms. Recent single-cell
studies on mouse fibroblasts have shown that the circadian clock and cell cycle systems are …

Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …

For many years, a connection between circadian clocks and cancer has been postulated.
Here we describe an unexpected function for the circadian repressor CRY2 as a component …

As a response to environmental changes driven by the Earth's axial rotation, most organisms
evolved an internal biological timer—the so called circadian clock—which regulates …

The circadian clock is a biological mechanism that dictates an array of rhythmic
physiological processes. Virtually all cells contain a functional clock whose disruption results …

The biological clock system is an intrinsic timekeeping device that integrates internal
physiology and external cues. Maintaining a healthy biological clock system is crucial for life …

The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …