[HTML][HTML] The diverse mechanisms and anticancer potential of naphthoquinones

CE Pereyra, RF Dantas, SB Ferreira, LP Gomes… - Cancer Cell …, 2019 - Springer
Cancer is one of the leading causes of death around the world and although the different
clinical approaches have helped to increase survival rates, incidence is still high and so its …

Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus

AA Adeniji, KE Knoll, DT Loots - Applied microbiology and biotechnology, 2020 - Springer
The latest WHO report estimates about 1.6 million global deaths annually from TB, which is
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …

[图书][B] Encyclopedia of dietary supplements

PM Coates, JM Betz, MR Blackman, GM Cragg… - 2010 - books.google.com
Encyclopedia of Dietary Supplements presents peer-reviewed, objective entries that
rigorously examine the most significant scientific research on basic chemical, preclinical …

Biological activity of 1, 2, 3-triazole-2-amino-1, 4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control

RMC Souza, LMLM Pimentel, LKM Ferreira… - European journal of …, 2023 - Elsevier
Malaria can be caused by several Plasmodium species and the development of an effective
vaccine is challenging. Currently, the most effective tool to control the disease is the …

[HTML][HTML] Evaluation of the genotoxicity and mutagenicity of isoeleutherin and eleutherin isolated from Eleutherine plicata herb. using bioassays and in silico …

ALG Castro, JN Cruz, DF Sodré… - Arabian Journal of …, 2021 - Elsevier
The biological activities of Eleutherine plicata Herb. have been linked to isoeleutherin and
eleutherin naphthoquinones. However, there are few reports in the literature regarding the …

[HTML][HTML] Spectroscopic and in silico evaluation on the interactive behavior between substituted β-2, 3-dihydrofuran naphthoquinones and human serum albumin

OA Chaves, CHC dos Santos Oliveira… - Chemical Physics …, 2024 - Elsevier
The interactive profile between human serum albumin (HSA, the main carrier of endogenous
and exogenous compounds in the human bloodstream) and five potential anticandidal …

[HTML][HTML] Participation of Oxidative Stress in the Activity of Compounds Isolated from Eleutherine plicata Herb

ARQ Gomes, JN Cruz, ALG Castro… - Molecules, 2023 - mdpi.com
From Eleutherine plicata, naphthoquinones, isoeleutherine, and eleutherol were isolated,
and previous studies have reported the antioxidant activity of these metabolites. The present …

Spectroscopic and in silico characterization of the interaction between synthetic 2-substituted-naphtho-1, 4-quinones and human serum albumin

ML da Silva Moreira, OA Chaves, NC de Lucas… - Journal of Molecular …, 2024 - Elsevier
The intermolecular interaction between 2-(N-phenyl-N-methyl) aminonaphtho-1, 4-quinone
(1) and 2-(4-N-methylaminophenyl) naphtho-1, 4-quinone (2) and human serum albumin …

[HTML][HTML] Antifungal Activity of Naphthoquinoidal Compounds In Vitro against Fluconazole-Resistant Strains of Different Candida Species: A Special Emphasis on Mechanisms of …

JBA Neto, CR da Silva, MAS Neta, RS Campos… - PLoS …, 2014 - journals.plos.org
In recent decades, the incidence of candidemia in tertiary hospitals worldwide has
substantially increased. These infections are a major cause of morbidity and mortality; in …

[HTML][HTML] Preclinical evaluation of L-fucoside from lapachol-loaded nanoemulsion as a strategy to breast cancer treatment

SEM Miranda, J de Alcantara Lemos, FM Ottoni… - Biomedicine & …, 2024 - Elsevier
Breast cancer prevails as the most common cancer in women, underscoring an urgent need
for more effective therapies. This study explores the potential of our newly developed …