Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are …

Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular
and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated …

Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of
several types of malignant cells both in vivo and in vitro. However, its mechanism of action …

A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …

The link between estrogen and the development and proliferation of breast cancer is well
documented. Estrogen stimulates growth and inhibits apoptosis through estrogen receptor …

Flavonoids belong to a category of polyphenolic compounds that are produced exclusively
in plants. These compounds are able to bring about various biological and pharmacological …

Chemotherapy is central to the current treatment modality for primary human brain tumors,
but despite high-dose and intensive treatment regimens there has been little improvement in …

In this study, we show that the novel synthetic curcumin analog, EF24, induces cell cycle
arrest and apoptosis by means of a redox-dependent mechanism in MDA-MB-231 human …

There has been increasing interest, in recent years, in the possibility that reactive
oxygen/nitrogen species (ROS/RNS) act as signals, or mediators of changes, in cell function …

Reactive oxygen species (ROS) have emerged as important signaling molecules in the
regulation of various cellular processes. They can be generated by the mitochondrial …