Abstract The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial
growth factor domain-containing protein] family consists of three proteins in vertebrates …

The 100th anniversary of the first description of Thrombotic Thrombocytopenic Purpura
(TTP) as a disease by Dr. Eli Moschcowitz approaches. For many decades, TTP remained …

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare medical emergency
for which a correct and early diagnosis is essential. As a severe deficiency in A Disintegrin …

The thrombotic microangiopathies (TMAs) are a heterogenous group of disorders with
distinct pathophysiologies that cause occlusive microvascular or macrovascular thrombosis …

Background ADAMTS-13 adopts an open conformation in patients with immune-mediated
thrombotic thrombocytopenic purpura (iTTP) in acute phase while being closed in healthy …

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an ultrarare thrombotic
disease caused by autoantibody-induced ADAMTS13 deficiency. Open ADAMST13 …

A finding of an ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type
1 motif, member 13) activity level of< 10% of normal is usually sufficient to distinguish …

Thrombotic thrombocytopenic purpura (TTP) is a fatal disease in which platelet-rich
microthrombi cause end-organ ischemia and damage. TTP is caused by markedly reduced …

A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13
(ADAMTS13) is a multidomain metalloprotease for which until now only a single substrate …

Thrombotic thrombocytopenic purpura (TTP) is a fatal disease in which platelet-rich
microthrombi cause end-organ ischemia and damage. TTP is caused by markedly reduced …