Epithelial-to-mesenchymal transition (EMT) and its reverse process MET naturally occur
during development and in tissue repair in vertebrates. EMT is also recognized as the …

Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue
homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are …

Glioblastoma progression in its early stages remains poorly understood. Here, we transfer
PDGFB and genetic barcodes in mouse brain to initiate gliomagenesis and enable direct …

Background A number of clinico-pathological criteria and molecular profiles have been used
to stratify patients into high-and low-risk groups. Currently, there are still no effective …

Despite many endeavors to treat malignant gliomas in the last decades, the median survival
of patients has not significantly improved. The infiltrative nature of high-grade gliomas and …

Abstract Background Recurrence of Glioblastoma multiforme (GBM) seems to be the rule
despite combination therapies. Cell invasion and cell proliferation are major reasons for …

Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are
the most lethal types of cancer in children. In recent years, it has become evident that these …

Recurrent miscarriage (RM) is currently defined as two or more losses of a clinically
established intrauterine pregnancy. Despite years of research, RM continues to be a …

Autophagy is an evolutionary conserved process mediating lysosomal degradation of
cytoplasmic material. Its involvement in cancer progression is highly controversial, due to its …

The homeobox protein cut-like 1 (CUX1) comprises three isoforms and has been shown to
be involved in the development of various types of malignancies. However, the expression …