Cortisol is involved in many physiological processes, including immunosuppressive and anti-
inflammatory actions, and therefore cortisol and its synthetic analogs are widely used to treat …

Glucocorticoids (GCs) are steroid hormones that influence several physiologic functions and
are among the most frequently prescribed drugs worldwide. Resistance to GCs has been …

Histories of early life stress (ELS) or social discrimination can reach levels of severity
characterized as toxic to mental and physical health. Such toxic social stress during …

Introduction: Corticosteroids are widely prescribed and their use has been linked to adverse
cardiometabolic outcomes. A pivotal role in the action of corticosteroids is reserved for the …

Context: The Bcl I polymorphism in the glucocorticoid receptor (GR) gene is associated with
enhanced glucocorticoid (GC) sensitivity. Objective: Our objective was to investigate the …

Aims The effect of excess glucocorticoid receptor (GR) stimulation through glucocorticoid
medication or cortisol on glucose metabolism is well established. There are genetic GR …

The regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with
polymorphisms and the methylation degree of the glucocorticoid receptor gene (NR3C1) …

Background The aim of this study was to investigate the occupational stress and
hypertension in desert petroleum workers in Xinjiang, and to analyze the association of …

Common variants in serotonin and corticosteroid receptor genes influence human stress in
laboratory settings. Little is known of their combined effects, especially in high stress …

OBJECTIVE Polymorphisms (SNP) in the glucocorticoid receptor (GR) gene can alter
sensitivity to glucocorticoids. Previous studies of the N363S and Bcl I SNP in the GR gene …