The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly
conserved mediators in the regulation of complex social cognition and behaviour. Recent …

The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of
physiological functions, including water reabsorption, cardiovascular homeostasis, hormone …

There are no specific structural neuropathological hallmarks found in the brain of mood
disorders. Instead, there are molecular, functional and structural alterations reported in many …

Parental care influences development across mammals. In humans such influences include
effects on phenotypes, such as stress reactivity, which determine individual differences in …

Stress is defined as a state of perturbed homeostasis following endangerment that evokes
manifold adaptive reactions, which are summarized as the stress response. In the case of …

The stress response is mediated by the hypothalamo–pituitary–adrenal (HPA) system.
Activity of the corticotropin-releasing hormone (CRH) neurons in the hypothalamic …

Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic
supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior …

Abstract Data from the Genetic Association Information Network (GAIN) genome-wide
association study (GWAS) in major depressive disorder (MDD) were used to explore …

Depression is a prevalent, highly debilitating mental disorder affecting up to 15% of the
population at least once in their lifetime, with huge costs for society. Neurobiological …

The genetic basis of major depressive disorder (MDD) has been investigated extensively,
but the identification of MDD genes has been hampered by conflicting results from …