Clinical validation of reduced alcohol consumption after treatment for alcohol dependence using the World Health Organization risk drinking levels
Background Alcohol use disorder (AUD) is a highly prevalent public health problem
associated with considerable individual and societal costs. Abstinence from alcohol is the …
associated with considerable individual and societal costs. Abstinence from alcohol is the …
Drinking risk level reductions associated with improvements in physical health and quality of life among individuals with alcohol use disorder
Background Abstinence and no heavy drinking days are currently the only Food and Drug
Administration–approved end points in clinical trials for alcohol use disorder (AUD). Many …
Administration–approved end points in clinical trials for alcohol use disorder (AUD). Many …
Evaluation of drinking risk levels as outcomes in alcohol pharmacotherapy trials: a secondary analysis of 3 randomized clinical trials
DE Falk, SS O'Malley, K Witkiewitz, RF Anton… - JAMA …, 2019 - jamanetwork.com
Importance The US Food and Drug Administration recognizes total abstinence and no heavy
drinking days as outcomes for pivotal pharmacotherapy trials for alcohol use disorder (AUD) …
drinking days as outcomes for pivotal pharmacotherapy trials for alcohol use disorder (AUD) …
What do clinicians want? Understanding frontline addiction treatment clinicians' preferences and priorities to improve the design of measurement-based care …
JS Tauscher, EB Cohn, TR Johnson… - Addiction Science & …, 2021 - Springer
Background Measurement-based care (MBC) is the practice of routinely administering
standardized measures to support clinical decision-making and monitor treatment progress …
standardized measures to support clinical decision-making and monitor treatment progress …
Preresolution drinking problem severity profiles associated with stable moderation outcomes of natural recovery attempts
Background Higher problem severity contraindicates moderation drinking in treatment
samples, but has not been well investigated in natural recovery samples with more prevalent …
samples, but has not been well investigated in natural recovery samples with more prevalent …
Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials
Background and aims There is evidence that low‐risk drinking is possible during the course
of alcohol treatment and can be maintained following treatment. Our aim was to identify …
of alcohol treatment and can be maintained following treatment. Our aim was to identify …
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Background Despite calls for non-abstinence endpoints in randomized clinical trials (RCTs)
for cocaine use disorder, there is a lack of data validating non-abstinence endpoints. We …
for cocaine use disorder, there is a lack of data validating non-abstinence endpoints. We …
Evaluating cannabis use risk reduction as an alternative clinical outcome for cannabis use disorder.
Objective: Abstinence is rarely achieved in clinical trials for cannabis use disorder (CUD).
Cannabis reduction is associated with functional improvement, but reduction endpoints have …
Cannabis reduction is associated with functional improvement, but reduction endpoints have …
Using peers to increase veterans' engagement in a smartphone application for unhealthy alcohol use: A pilot study of acceptability and utility.
DM Blonigen, B Harris-Olenak, E Kuhn… - Psychology of …, 2021 - psycnet.apa.org
Mobile apps can only increase access to alcohol treatment if patients actively engage with
them. Peers may be able to facilitate such engagement by providing supportive …
them. Peers may be able to facilitate such engagement by providing supportive …
Effects of arousal modulation via resonance breathing on craving and affect in women with substance use disorder
Background Craving for alcohol and other drugs is a complex in-the-moment experience
that involves within-person changes in physiological arousal and affect. We evaluated the …
that involves within-person changes in physiological arousal and affect. We evaluated the …