Poly (2-oxazoline) s based biomaterials: A comprehensive and critical update

T Lorson, MM Luebtow, E Wegener, MS Haider… - Biomaterials, 2018 - Elsevier
Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …

The chemistry of poly (2-oxazoline) s

B Verbraeken, BD Monnery, K Lava… - European Polymer …, 2017 - Elsevier
As we celebrate the 50th birthday of the discovery of poly (2-alkyl/aryl-2-oxazoline) s (PAOx)
this year we see a research field that is rapidly expanding after some lesser academic …

Amidation of methyl ester-functionalised poly (2-oxazoline) s as a powerful tool to create dual pH-and temperature-responsive polymers as potential drug delivery …

MN Leiske, R Singha, S Jana, BG De Geest… - Polymer …, 2023 - pubs.rsc.org
In the past two decades, thermoresponsive polymers based on tertiary amine groups have
been studied extensively as a class of dual-responsive polymers. In particular, their …

Poly (2-oxazoline) s and click chemistry: A versatile toolbox toward multi-functional polymers

K Lava, B Verbraeken, R Hoogenboom - European Polymer Journal, 2015 - Elsevier
Abstract Poly (2-alkyl/aryl-2-oxazoline) s (PAOx) have been gaining increasing attention
because they combine biocompatibility with so-called stealth behavior, making them ideal …

A thermogelling supramolecular hydrogel with sponge-like morphology as a cytocompatible bioink

T Lorson, S Jaksch, MM Lübtow, T Jüngst… - …, 2017 - ACS Publications
Biocompatible polymers that form thermoreversible supramolecular hydrogels have gained
great interest in biomaterials research and tissue engineering. When favorable rheological …

In situ functionalized polymers for siRNA delivery

JM Priegue, DN Crisan, J Martínez‐Costas… - Angewandte …, 2016 - Wiley Online Library
A new method is reported herein for screening the biological activity of functional polymers
across a consistent degree of polymerization and in situ, that is, under aqueous conditions …

The influence of polymer architecture on in vitro pDNA transfection

AC Rinkenauer, S Schubert, A Traeger… - Journal of Materials …, 2015 - pubs.rsc.org
In 2012, the first gene therapy agent was approved by the Europe Medicines Agency
leading to increased interest in this research field. Beside viruses, non-viral agents based on …

Molecular insights into site-specific interferon-α2a bioconjugates originated from PEG, LPG, and PEtOx

N Hauptstein, P Pouyan, J Kehrein, M Dirauf… - …, 2021 - ACS Publications
Conjugation of biologics with polymers modulates their pharmacokinetics, with polyethylene
glycol (PEG) as the gold standard. We compared alternative polymers and two types of …

Hyperbranched poly (ethylenimine-co-oxazoline) by thiol–yne chemistry for non-viral gene delivery: investigating the role of polymer architecture

AB Cook, R Peltier, J Zhang, P Gurnani, J Tanaka… - Polymer …, 2019 - pubs.rsc.org
Cationic polymers have been widely employed as gene delivery vectors to help circumvent
extracellular and intracellular delivery barriers. Among them, polyethylenimine (PEI) is the …

Crossing the blood-brain barrier: Glutathione-conjugated poly (ethylene imine) for gene delivery

C Englert, AK Trützschler, M Raasch, T Bus… - Journal of Controlled …, 2016 - Elsevier
The targeted drug delivery to the central nervous system represents one of the major
challenges in pharmaceutical formulations since it is strictly limited through the highly …