Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Obesity has become a global epidemic that has a negative impact on population health and
the economy of nations. Genetic predispositions have been demonstrated to have a …

Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

In considering an overview of microRNA biology, it is useful to consider microRNAs as a part
of cellular communication. At the simplest level, microRNAs act to decrease the expression …

Preservation of aerobic fitness and skeletal muscle strength through exercise training can
ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated …

Endurance exercise-mediated multisystemic adaptations are known to mitigate metabolism-
related disorders such as obesity and type 2 diabetes mellitus (T2DM). However, the …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

MiRNAs are potent intracellular posttranscriptional regulators and are also selectively
secreted into the circulation in a cell-specific fashion. Global changes in miRNA expression …

Key points Recent studies have indicated that antioxidant supplementation may blunt
adaptations to exercise, such as mitochondrial biogenesis induced by endurance training …

Non‐technical summary MicroRNA (miRNA) molecules are essential intracellular mediators
of numerous biological processes including angiogenesis, inflammation, and mitochondrial …