Which compound classes are best suited as probes and tools for chemical biology research
and as inspiration for medicinal chemistry programs? Chemical space is enormously large …

Covering: July 2007 to June 2010. Previous review: Nat. Prod. Rep., 2009, 26, 382–445 A
great number of structurally diverse natural products containing five-membered heterocyclic …

For scientists to gain a better understanding of nature, biological research is greatly aided by
small-molecule modulators that perturb protein activity without fundamentally altering the …

Recent advances in end-to-end continuous-flow synthesis are rapidly expanding the
capabilities of automated customized syntheses of small-molecule pharmacophores …

Searching for efficient strategies to access structurally novel aminoindolines is of great
significance for drug discovery. However, catalytic asymmetric de novo construction of …

In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

A central aim of biological research is to elucidate the many roles of proteins in complex,
dynamic living systems; the selective perturbation of protein function is an important tool in …

The chromone and flavonoid alkaloids represent an unusual group of structurally diverse
secondary metabolites, derived from the convergence of multiple biosynthetic pathways that …

Through the natural selection process, natural products possess a unique and vast chemical
diversity and have been evolved for optimal interactions with biological macromolecules …

Dendrimers, by virtue of their unique well-defined dendritic structure and multivalent
cooperativity, hold great promise for a wide variety of applications, ranging from healthcare …