A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Amyloid fibrils have traditionally been considered only as pathological aggregates in human
neurodegenerative diseases, but it is increasingly becoming clear that the propensity to form …

For several decades scientists have speculated that the key to understanding age-related
neurodegenerative disorders may be found in the unusual biology of the prion diseases …

Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several
neurodegenerative diseases, including Alzheimer's disease. In the disease process …

The concept of molecular mimicry was established to explain commonalities of structure
which developed in response to evolutionary pressures. Most examples of molecular …

The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …

Recent evidence indicates that diverse neurodegenerative diseases might have a common
cause and pathological mechanism—the misfolding, aggregation and accumulation of …

A key molecular pathway implicated in diverse neurodegenerative diseases is the
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …

The once heretical concept that a misfolded protein is the infectious agent responsible for
prion diseases is now widely accepted. Recent exciting research has led not only to the end …

Some of the most prevalent human degenerative diseases appear as a result of the
misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein …