Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

PRIMPOL repriming allows DNA replication to skip DNA lesions, leading to ssDNA gaps.
These gaps must be filled to preserve genome stability. Using a DNA fiber approach to …

The BRCA1–BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …

The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

The mechanisms contributing to transcription-associated genomic instability are both
complex and incompletely understood. Although R-loops are normal transcriptional …

DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …

Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …

Accumulation of repair proteins on damaged chromosomes is required to restore genomic
integrity. However, the mechanisms of protein retention at the most destructive chromosomal …