The effect of the pineal indole hormone melatonin on the life span of mice, rats and fruit flies
has been studied using various approaches. It has been observed that in female CBA, SHR …

Cellular senescence is an important phenomenon in decreased cellular function. Recently, it
was shown that cellular senescence is induced in proliferating cells within a short period of …

A number of molecular methods of gene expression analysis can approach genomic level.
Among those, Serial Analysis of Gene Expression (SAGE) stands out. Unlike many other …

In the aging heart, decreased rates of calcium transport mediated by the SERCA2a isoform
of the sarcoplasmic reticulum (SR) Ca-ATPase are responsible for the slower sequestration …

Heart failure (HF) is the end result of progressive and diverse biological adaptations within
the diseased myocardium. We used cDNA microarrays and quantitative PCR to examine the …

Abstract Serial Analysis of Gene Expression was used to define number and relative
abundance of transcripts in the root tip of well-watered maize seedlings (Zea mays cv …

It has been 7 years since serial analysis of gene expression (SAGE) and microarray
hybridization techniques were simultaneously introduced to allow the screening of …

APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of
action of APOE in AD remains unclear. To study the effects of APOE alleles on gene …

Genomic convergence is a multistep approach that combines gene expression with genomic
linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we …

The serial analysis of gene expression (SAGE) method is used to study global gene
expression in cells or tissues in various experimental conditions. However, its reproducibility …