Pathophysiology and treatment of memory dysfunction after traumatic brain injury

R Paterno, KA Folweiler, AS Cohen - Current neurology and neuroscience …, 2017 - Springer
Memory is fundamental to everyday life, and cognitive impairments resulting from traumatic
brain injury (TBI) have devastating effects on TBI survivors. A contributing component to …

[HTML][HTML] Hippocampal neurophysiologic changes after mild traumatic brain injury and potential neuromodulation treatment approaches

F Girgis, J Pace, J Sweet, JP Miller - Frontiers in systems …, 2016 - frontiersin.org
Traumatic brain injury (TBI) is the leading cause of death and disability in individuals below
age 45, and five million Americans live with chronic disability as a result. Mild TBI (mTBI) …

[HTML][HTML] TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

J Yan, Y Zhang, L Wang, Z Li, S Tang, Y Wang… - Journal of …, 2022 - Springer
Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …

Deep brain stimulation for the treatment of disorders of consciousness and cognition in traumatic brain injury patients: a review

B Kundu, AA Brock, DJ Englot, CR Butson… - Neurosurgical …, 2018 - thejns.org
Traumatic brain injury (TBI) is a looming epidemic, growing most rapidly in the elderly
population. Some of the most devastating sequelae of TBI are related to depressed levels of …

[HTML][HTML] The medial septum as a potential target for treating brain disorders associated with oscillopathies

Y Takeuchi, AJ Nagy, L Barcsai, Q Li… - Frontiers in Neural …, 2021 - frontiersin.org
The medial septum (MS), as part of the basal forebrain, supports many physiological
functions, from sensorimotor integration to cognition. With often reciprocal connections with …

[HTML][HTML] Forebrain cholinergic signaling regulates innate immune responses and inflammation

KR Lehner, HA Silverman, ME Addorisio… - Frontiers in …, 2019 - frontiersin.org
The brain regulates physiological functions integral to survival. However, the insight into
brain neuronal regulation of peripheral immune function and the neuromediator systems …

[HTML][HTML] Mechanisms for cognitive impairment in epilepsy: moving beyond seizures

MR Khalife, RC Scott, AE Hernan - Frontiers in neurology, 2022 - frontiersin.org
There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …

[HTML][HTML] Disruption of network synchrony and cognitive dysfunction after traumatic brain injury

JA Wolf, PF Koch - Frontiers in systems neuroscience, 2016 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder with many factors contributing to a
spectrum of severity, leading to cognitive dysfunction that may last for many years after …

Neuromodulation therapies in pre-clinical models of traumatic brain injury: systematic review and translational applications

S Surendrakumar, TK Rabelo, ACP Campos… - Journal of …, 2023 - liebertpub.com
Traumatic brain injury (TBI) has been associated with several lasting impairments that affect
quality of life. Pre-clinical models of TBI have been studied to further our understanding of …

Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy

ER Cole, DP Grogan, NG Laxpati, AM Fernandez… - …, 2022 - Wiley Online Library
Electrical brain stimulation has become an essential treatment option for more than one third
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …